PSMA I&T acetate (GMP)

Precursor for radiometal-labelled PSMA I&T
PSMA: prostate-specific membrane antigen

Structurformel

Manufactured according to GMP requirements for APIs for use in clinical trials (ICH Q7 chapter 19)

Molar Mass: 1498,37
C63H92IN11O23
[2192281-54-0] (net peptide)

Colourless to off-white solid

Purity: > 95 %

Certificates:
  • CoA
  • ;
  • HPLC (Purity)
  • ;
  • MS (identity)

Chemical Name: Sequence: Glu-CO-Lys[(Sub)DLys-DPhe-DTyr(3I)-DOTAGA] acetate

Literature:
  1. Schottelius M. et al. [111In] PSMA-I&T: expanding the spectrum of PSMA-I&T applications towards SPECT and radioguided surgery. EJNMMI Res. 2015, 5, 68.
  2. Baum R.P. et al. 177Lu-Labeled Prostate-Specific Membrane Antigen Radioligand Therapy of Metastatic Castration-Resistant Prostate Cancer: Safety and Efficacy. J. Nucl. Med. 2016, 57, 1006-1013.
  3. Eiber M. et al. Systemic Radioligand Therapy with (177)Lu Labeled Prostate Specific Membrane Antigen Ligand for Imaging and Therapy in Patients with Metastatic Castration Resistant Prostate Cancer. J. Nucl. Med., 2016, 57(supplement 2): p. 61-61.
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