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ABX  advanced biochemical compounds   

Product Order number / Unit

2070 GR 89696 fumarate 2070.0001: 1 mg per vial
2070.0005: 5 mg per vial
2070.0010: 10 mg per vial
Please inquire for customized filling and bulk quantities.

Reference standard for (R)-(-)-[11C]GR 103545
and (S)-(+)-[11C]GR 103545

Highly potent and selective κ opioid receptor agonist
Molar Mass: 530.40
C19H25Cl2N3O3 ⋅ C4H4O4
Off-white solid packaged in dark glass crimp cap vials.
Purity: > 95 %
CoA; 1H and 13C NMR spectra
Chemical Name:
CA index name: 1-Piperazinecarboxylic acid, 4-[(3,4-dichlorphenyl)acetyl]-3-(1-pyrrolidinylmethyl)-, methyl ester, (E)-2-butenedioate (1:1)
GR 89696 fumarate salt; 4-[(3,4-dichlorphenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate
Ravert H.T. et al. [11C]-GR 89696, a potent kappa opiate receptor radioligand; in vivo binding of the R and S enantiomers. Nuc. Med. Biol. 2002, 29, 47-53.
Talbot P.S. et al. 11C-GR 103545, a Radiotracer for Imaging κ-Opioid Receptors In Vivo with PET: Synthesis and Evaluation in Baboons. J. Nucl. Med. 2005, 46, 484-494.
Naylor A. et al. A Potent New class of κ-Receptor Agonist: 4-Substituted 1-(Arylacetyl)-2-[(dialkylamino)methyl]piperazines. J. Med. Chem. 1993, 36, 2075-2083.
Schoultz B.W. et al. A New Method for Radiosynthesis of 11C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [11C]GR 103545. The Open Med. Chem. J. 2008, 2 ,72-74.
date of product catalogue issue: 10 May 2017


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