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ABX  advanced biochemical compounds   

Product Order number / Unit

3371 ASEM precursor 3371.0010: 10 mg per vial
Please inquire for customized filling and bulk quantities.

Precursor for [18F]ASEM
Molar Mass: 385.44
Reddish solid packaged in dark glass crimp cap vials.
Purity: > 95 %
CoA; 1H spectrum
Chemical Name:
3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-nitrodibenzo[b,d]thiophene 5,5-dioxide
[18F]ASEM precursor; [18F]JHU82132 precursor; 4-(6-Nitro-5,5-dioxo-5H-5l6-dibenzothiophen-3-yl)-1,4-diaza-bicyclo[3.2.2]nonane
Gao Y. et al. Derivatives of dibenzothiophene for positron emission tomography imaging of α7-nicotinic acetylcholine receptors. J. Med. Chem. 2013, 56, 7574-7589.
Horti A.G. et al. 18F-ASEM, a Radiolabeled Antagonist for Imaging the α7-Nicotinic Acetylcholine Receptor with PET. J. Nucl. Med. 2014, 55, 672-677.
Wong D.F. et al. Human Brain Imaging of α7 nAChR with [18F]ASEM: a New PET Radiotracer for Neuropsychiatry and Determination of Drug Occupancy. Mol. Imaging Biol. 2014, 16, 730-738.
Horti A.G. Development of [18F]ASEM, a specific radiotracer for quantification of the α7-nAChR with positron-emission tomography. Biochem. Pharmacol. 2015, 97, 566-575.
Ravert H.T. et al. Microwave-assisted radiosynthesis of [18F]ASEM, a radiolabeled α7-nicotinic acetylcholine receptor antagonist. J. Labelled Compd. Radiopharm. 2015, 58, 180-182.
date of product catalogue issue: 10 May 2017


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