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ABX  advanced biochemical compounds   

Product Order number / Unit

6040 (S)-(+)-Desmethyl-Rolipram 6040.0010: 10 mg per vial
Please inquire for customized filling and bulk quantities.

Precursor for S-(+)-[11C]Rolipram
Molar Mass: 261.32
Colourless solid packaged in dark glass screw cap vials.
Purity: > 95 %
CoA; 1H NMR spectrum
Chemical Name:
CA index name: 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-hydroxyphenyl]-, (4S)-
S-Desmethyl-Rolipram; (+)-Desmethyl-Rolipram
Kenk M. et al. In vivo selective binding of (R)-[11C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues. Nucl. Med. Biol. 2007, 34, 71-77.
Parker C.A. et al. Behaviour of [11C]R(-)- and [11C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4. Synapse 2005, 55, 270-279.
Lourenco C.M. et al. Characterization of R-[11C]rolipram for PET imaging of phosphodiesterase-4: in vivo binding, metabolism, and dosimetry studies in rats. Nucl. Med. Biol. 2001, 28, 347-358.
Tsukada H. et al. Facilitation of dopaminergic neural transmission does not affect [11C]SCH23390 binding to the striatal D1 dopamine receptors, but the facilitation enhances phosphodiesterase type-IV actvity through D1 receptors: PET studies in the conscious monkey brain. Synapse 2001, 42, 258-265.
date of product catalogue issue: 10 May 2017


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