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ABX  advanced biochemical compounds   


Catalogue
Number
Product Order number / Unit

9510 PMPA
Please inquire for customized filling and bulk quantities.

 
Inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated α-linked dipeptidase/NAALADase)
Molar Mass: 226.12
C6H11O7P
[173039-10-6]
colourless highly viskous oil packaged in dark glass vials.
Bitte Patentschutz klären.
Purity: > 95 %
Certificates:
CoA; 1H NMR spectrum
Chemical Name:
2-(Phosphonomethyl)pentane-1,5-dioic acid
Synonymes:
PMPA (NAALADase inhibitor)
Literature:
Jackson et al. Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase. J.Med.Chem. 1996, 39, 619
Slusher et al. Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat.Med. 1999, 5, 1396
Thomas et al. NAALADase inhibition protects motor neurons against chronic glutamate toxicity. Eur.J.Pharmacol. 2003, 471, 177
date of product catalogue issue: 10 May 2017

 
 
 

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