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ABX  advanced biochemical compounds   

Product Order number / Unit

9941 deprotected DCFPyL precursor 9941.0010: 10 mg per vial
Please inquire for customized filling and bulk quantities.

Precursor for [18F]DCFPyL
2-(3-{1-carboxy-5-[(6-[18F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid
Research Chemical
The tracer [18F]DCFPyL is patent-protected in some countries, please consider to inquire for PSMA-1007 compounds (ID 9943, 99433) instead, that are provided by ABX under exclusive licence.
Molar Mass: 595.52
CAS-RN not yet assigned
Colourless to off-white solid packaged in dark glass crimp cap vials.
Purity: > 95 %
CoA; 1H NMR spectrum (identity); HPLC (purity)
Chemical Name:
5-((S)-5-carboxy-5-(3-((S)-1,3-dicarboxypropyl)ureido)pentylcarbamoyl)-N,N,N-trimethylpyridin-2-aminium 2,2,2-trifluoroacetate
deprotected [18F]DCFPyL precursor; 5-((S)-5-carboxy-5-(3-((S)-1,3-dicarboxypropyl)ureido)pentylcarbamoyl)-pyridin-2-yl-trimethylammonium 2,2,2-trifluoroacetate
Chen Y. et al. 2-(3-{1-Carboxy-5-[(6-[18F]Fluoro-Pyridine-3-Carbonyl)-Amino]-Pentyl}-Ureido)-Pentanedioic Acid, [18F]DCFPyL, a PSMA-Based PET Imaging Agent for Prostate Cancer. Clin. Cancer. Res. 2011, 17, 7645-7653.
Szabo Z. et al. Initial Evaluation of [18F]DCFPyL for Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer. Mol. Imaging Biol. 2015, 17, 565-574.
Rowe S.P. et al. Imaging of metastatic clear cell renal cell carcinoma with PSMA-targeted 18F-DCFPyL PET/CT. Ann. Nucl. Med. 2015, 29, 877-882.
Rowe S.P. et al. Detection of 18F-FDG PET/CT occult lesions with 18F-DCFPyL PET/CT in a patient with metastatic renal cell carcinoma. Clin. Nucl. Med. 2016, 41, 83-85.
Dietlein M. et al. Comparison of [18F]DCFPyL and [68Ga]Ga-PSMA-HBED-CC for PSMA-PET Imaging in Patients with Relapsed Prostate Cancer. Mol. Imaging Biol. 2015, 17, 575-584.
date of product catalogue issue: 24 February 2017


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