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ABX  advanced biochemical compounds   

Product Order number / Unit

9943 PSMA-1007 precursor 9943.0003: 3 mg per vial
Please inquire for customized filling and bulk quantities.

Precursor for [18F]PSMA-1007
PSMA: prostate-specific membrane antigen
Research Chemical
Molar Mass: 1184.13
CAS-RN not yet assigned
Colourless to off-white solid packaged in dark glass crimp cap vials.
Purity: > 95 %
CoA; 1H NMR spectrum (identity); HPLC (purity)
Chemical Name:
5-((S)-4-carboxy-1-((S)-4-carboxy-1-(4-((S)-1-((S)-5-carboxy-5-(3-((S)-1,3-dicarboxypropyl)ureido)pentylamino)-3-(naphthalen-2-yl)-1-oxopropan-2-ylcarbamoyl)benzylamino)-1-oxobutan-2-ylamino)-1-oxobutan-2-ylcarbamoyl)-N,N,N-trimethylpyridin-2-aminium 2,2,2-trifluoroacetate
deprotected [18F]PSMA-1007 precursor; Glu-CO-Lys(2Nal-Amb-Glu-Glu-PyTMA); EuK(2Nal-Amb-Glu-Glu-PyTMA); 5-((S)-4-carboxy-1-((S)-4-carboxy-1-(4-((S)-1-((S)-5-carboxy-5-(3-((S)-1,3-dicarboxypropyl)ureido)pentylamino)-3-(naphthalen-2-yl)-1-oxopropan-2-ylcarbamoyl)benzylamino)-1-oxobutan-2-ylamino)-1-oxobutan-2-ylcarbamoyl)-pyridin-2-yl-trimethylammonium 2,2,2-trifluoroacetate
Giesel F.L. et al. 18F-*PSMA-1007* PET/CT Detects Micrometastases in a Patient With Biochemically Recurrent Prostate Cancer. Clin. Genitourin. Cancer. 2016. doi: 10.1016/j.clgc.2016.12.029.
Giesel F.L. F-18 labelled *PSMA-1007*: biodistribution, radiation dosimetry and histopathological validation of tumor lesions in prostate cancer patients. Eur. J. Nucl. Med. Mol. Imaging 2017, 44(4), 678-688. doi: 10.1007/s00259-016-3573-4.
Cardinale J. et al. Preclinical Evaluation of [18F]PSMA-1007: A New PSMA-Ligand for Prostate Cancer Imaging. J. Nucl. Med. 2016. doi: 10.2967/jnumed.116.181768
Giesel F.L. et al. 18F-Labelled PSMA-1007 shows similarity in structure, biodistribution and tumour uptake to the theragnostic compound PSMA-617. Eur. J. Nucl. Med. Biol. 2016, 43, 1929-30.
Kesch C. et al. Intra-individual comparison of 18F-PSMA-1007-PET/CT, multi-parametric MRI and radical prostatectomy specimen in patients with primary prostate cancer - a retrospective, proof of concept study. J Nucl Med. 2017 doi: 10.2967/jnumed.116.18923
date of product catalogue issue: 10 May 2017


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