Reference standard for [¹⁸F]PBR06 and [¹¹C]PBR06
N-(2,5-Dimethoxy-benzyl)-2-fluoro-N-(2-phenoxy-phenyl)-acetamide; Acetamide, N-[(2,5-dimethoxyphenyl)methyl]-2-fluoro-N-(2-phenoxyphenyl)-
Molar mass 395.42
CAS RN [1104493-11-9]
Purity ≥ 95 %
- colorless to milky yellowish oil
- soluble in dimethyl sulfoxide, chloroform, ethyl acetate
CoA: appearance, ¹H and ¹⁹F-NMR spectra, HPLC (Purity)
Imaizumi M. et al. Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain. Synapse 2007, 61, 595–605.
Briard E. et al. Single-Step High-Yield Radiosynthesis and Evaluation of a Sensitive ¹⁸F-Labeled Ligand for Imaging Brain Peripheral Benzodiazepine Receptors with PET. J. Med. Chem. 2009, 52, 688–699.
Wang M. et al. Synthesis of [¹¹C]PBR06 and [¹⁸F]PBR06 as agents for positron emission tomographic (PET) imaging of the translocator protein (TSPO). Steroids 2011, 76, 1331–1340.
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