Reference standard for [¹¹C]Rolipram
4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone; (±)-Rolipram; (R,S)-Rolipram; SB 95952; ZK 62711
CA index name: 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-
Molar mass 275.35
CAS RN [61413-54-5]
Purity ≥ 95 %
- Yellowish solid
CoA: appearance, ¹H NMR spectrum
Kenk M. et al. In vivo selective binding of (R)-[¹¹C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues. Nucl. Med. Biol. 2007, 34, 71–77.
Parker C.A. et al. Behaviour of [¹¹C]R(–)- and [¹¹C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4. Synapse 2005, 55, 270–279.
Lourenco C.M. et al. Characterization of R-[¹¹C]rolipram for PET imaging of phosphodiesterase-4: in vivo binding, metabolism, and dosimetry studies in rats. Nucl. Med. Biol. 2001, 28, 347–358.
Tsukada H. et al. Facilitation of dopaminergic neural transmission does not affect [¹¹C]SCH23390 binding to the striatal D1 dopamine receptors, but the facilitation enhances phosphodiesterase type-IV actvity through D1 receptors: PET studies in the conscious monkey brain. Synapse 2001, 42, 258–265.
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|/products/chemicals/chemical/2e06ed84-8465-47b4-ba6a-627e3cd66ea6||Reference Standard||Product No.: 6000||Filling amount: 10 mg|
|/products/chemicals/chemical/2e06ed84-8465-47b4-ba6a-627e3cd66ea6||Reference Standard||Product No.: 6000|