CHEMICALS

(–)-McN 5652

Reference standard for (–)-[¹¹C]McN 5652

Pyrrolo[2,1-a]isoquinoline, 1,2,3,5,6,10b-hexahydro-6-[4-(methylthio)phenyl]-, (6R,10bS)-, (2S,3S)-2,3-di-(O-4-methylphenyloxy)butanedioate; (–)-McN 5652, (+)-di-O-toluyltartrate salt

CA index names: Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)-, compd. with (6R,10bS)-1,2,3,5,6,10b-hexahydro-6-[4-(methylthio)phenyl]pyrrolo[2,1-a]isoquinoline (1:1); Pyrrolo[2,1-a]isoquinoline, 1,2,3,5,6,10b-hexahydro-6-[4-(methylthio)phenyl]-, (6R,10bS)-, (2S,3S)-2,3-bis[(4-methylbenzoyl)oxy]butanedioate (1:1)

Quality

Research Chemical

Characteristics

Molar mass 681.79

CAS RN [262352-33-0]

Purity ≥ 95 %

  • Colorless solid

Certificates

CoA: appearance, ¹H and ¹³C NMR spectra

Literature

Zessin J. et al. Efficient Synthesis of Enantiomerically Pure Thioester Precursors of [¹¹C]MCN-5652 from Racemic MCN-5652. J. Labelled Compd. Radiopharm. 1999, 42, 1301–12.

Parsey R.V. et al. In Vivo Quantification of Brain Serotonin Transporters in Humans Using [¹¹C]McN 565J. Nucl. Med. 2000, 41, 1465–1477.

Buck A. et al. Evaluation of Serotonergic Transporters Using PET and [¹¹C]McN 5652: Assessment of Methods. J. Cereb. Blood Flow Metab. 2000, 20, 253–262.

Suehiro M. et al. An improved method for the synthesis of radiolabeled McN5652 via thioester precursors. Nucl. Med. Biol. 1995, 22, 543–5.

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