CHEMICALS

DOTA-NAPamide trifluoroacetate

Precursor for radiolabelled DOTA-NAPamide

[Nle4,Asp5,D-Phe7, Lys11(DOTA)]-α-MSH(4-11); CA index name: L-Lysinamide, N-acetyl-L-norleucyl-L-α-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophylglycyl-N⁶-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-

Sequence: Ac-Nle-Asp-His-D-Phe-Arg-Trp-Gly-Lys(DOTA)-NH₂

Quality

Research Chemical

Characteristics

Molar mass 1485.65

CAS RN [935886-72-9] (net peptide)

Purity ≥ 95 %

  • Colorless to off-white freeze-dried solid

Certificates

CoA: appearance, MS (identity), HPLC (purity)

Literature

Froidevaux S. et al. A Gallium-Labeled DOTA-α-Melanocyte-Stimulating Hormone Analog for PET Imaging of Melanoma Metastases. J. Nucl. Med. 2004, 45, 116–123.

Froidevaux S. et al. Melanoma Targeting with DOTA-α-Melanocyte-Stimulating Hormone Analogs: Structural Parameters Affecting Tumor Uptake and Kidney Uptake. J. Nucl. Med. 2005, 46, 887–895.

Cheng Z. et al. Cu-Labeled α-Melanocyte-Stimulating Hormone Analog for MicroPET Imaging of Melanocortin 1 Receptor Expression. Bioconjugate Chem. 2007, 18, 765–772.

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