Reference standard for S-(–)-[*I]IBZM and precursor for S-(–)-[¹²³/¹²⁵I-Tracer]IBZM
CA index name: Benzamide, N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-3-iodo-6-methoxy-
Molar mass 404.24
CAS RN [84226-06-2]
Purity ≥ 95 %
- Dark yellow oil
CoA: appearance, ¹H NMR spectrum
Kung H.F. et al. Dopamine D-2 receptor Imaging Radiopharmaceuticals: Synthesis, Radiolabeling and in Vitro binding of R(+)- and S(–)-3-iodo-2-hydroxy-6-methoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide. J. Med. Chem. 1988, 31, 1039–1043.
Cordes M. et al. Initial experience with SPECT examinations using [¹²³I]IBZM as a D2-dopamine receptor antagonist in Parkinson's disease. Eur. J. Radiol. 1991, 12, 182.
Innis R.B. et al. Amphetamine-stimulated dopamine release competes in vivo for [¹²³I]IBZM binding to the D2receptor in nonhuman primates. Synapse 1992, 10, 177.
Ichise M. et al. Iodine-123-IBZM dopamine D2receptor and technetium -99 m-HMPAO brain perfusion SPECT in the evaluation of patients with and subjects at risk for Huntington's disease J. Nucl. Med. 1993, 34, 1274.
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