CHEMICALS

Y-DOTA-TOC

Reference Standard for ⁹⁰Y-DOTA-TOC

natY-Edotreotide; natY-SMT487; natY-DOTA-[Tyr3]octreotide; Yttrium, [N-[2-[4,7,10-tris[(carboxy-κO)methyl]-1,4,7,10-tetraazacyclododec-1-yl-κN¹,κN⁴,κN⁷,κN¹⁰]acetyl-κO]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-L-cysteinamide cyclic (2→7)-disulfidato(3-)]-

Sequence: DOTA(Y)-D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr(ol), cyclic disulfide.

Quality

Research Chemical

Characteristics

Molar mass 1507.52 (net peptide)

CAS RN [293295-66-6]

Purity ≥ 95 %

  • Colorless to off-white solid

Certificates

CoA: appearance, MS (identity), HPLC (purity)

Literature

Villard L. et al. Cohort study of somatostatin-based radiopeptide therapy with [⁹⁰Y-DOTA]-TOC versus [⁹⁰Y-DOTA]-TOC plus [¹⁷⁷Lu-DOTA]-TOC in neuroendocrine cancers. J. Clin. Oncol. 2012, 30, 1100–1106.

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