Reference standard for [¹⁸F]SDM-8
(R)-4-(3,5-difluorophenyl)-1-((3-methylpyridin-4-yl)methyl)pyrrolidin-2-one; 2-Pyrrolidinone, 4-(3,5-difluorophenyl)-1-[(3-methyl-4-pyridinyl)methyl]-, (4R)-; SDM-8 standard
Molar mass 302.32
CAS RN [2242777-37-1]
Purity ≥ 95 %
- Colorless to off-white solid
- soluble in dimethyl sulfoxide, dichloromethane, methanol, ethyl acetate
CoA: appearance, ¹H and ¹⁹F NMR spectra (identity), HPLC (purity), chiral HPLC (enantiomeric purity)
Li S. et al. Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates. ACS Chem. Neurosci. 2019, 10, 1544–1554.
Li S. et al. ¹⁸F-SDM-8: A novel radiotracer for PET imaging of synaptic density. J. Nucl. Med. 2018, 59, supplement 1, 68.
Li S. et al. First-in-human Evaluation of ¹⁸F-SDM-8, A Novel Radiotracer for PET Imaging of Synaptic Vesicle Glycoprotein 2A. J. Nucl. Med. 2019, 60, supplement 1, 49.
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