Precursors, APIs and Standards

TetraBoc-L-DOPA methylester (GMP)

Boc4DOPA(2-SnMe3) methyl ester; N,N-di-tert-butoxycarbonyl-3,4-di-tert-butoxycarbonyloxy-6 (trimethylstannyl)-L-phenylalanine methyl ester; L-Tyrosine, N,N,O-tris[(1,1-dimethylethoxy)carbonyl]-5-[[(1,1-dimethylethoxy)carbonyl]oxy]-2 (trimethylstannyl)-, methyl ester

N-tert-butoxycarbonyl-3,4-di-tert-butoxycarbonyloxy-6-(trimethylstannyl)-L-phenylalanine methyl ester

Quality

GMP Product

Characteristics

Molar mass 774.49

CAS RN 2015236-76-5

Purity ≥ 97%

  • colourless to yellowish solid
  • soluble in ethyl acetate, chloroform, dichloromethane, diethyl ether, n-hexane

Certificates

1H-NMR, HPLC

Literature

Makaravage K. J. et al. Copper-Mediated Radiofluorination of Arylstannanes with [¹⁸F]KF. Org. Lett. 2016, 18, 5440–5443.

Kniess, T. et al. Cu-mediated 18F-radioflourination of various stannylated FDOPA precursors - what is feasible?, 25th International Symposium on Radiopharmaceutical Sciences (iSRS), 2023 Honolulu, Hawaii, 2023; Nucl. Med. Biol. 2023, 126–127, Suppl. 108754, P-293.

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