The nucleophilic method for production of [18F]F-L-DOPA developed by Coenen et al. uses an isotopic [18F]-fluorine-[19F]fluorine exchange and provides [18F]F-L-DOPA in good yield but with low specific activity. Based on the approach by Coenen et al., ABX developed a new precursor which allows the nucleophilic synthesis of [18F]F-L-DOPA using mild conditions suitable for a disposable kit. The one-pot production with simple cartridge cleaning is a reliable and convenient method for routine clinical production. As the process allows the application of mild temperatures and reagents, only three minor by-products have been detected which are easily removed using SPE to finally provide a solution of [18F]-L-DOPA with high specific activity and enantiomeric purity.
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ABX advanced biochemical compounds is a global frontrunner in radiopharmaceuticals, with a focus on positron emission tomography (PET) tracers. We develop and produce all compounds and components for any kind of radiotracer – from PET and SPECT precursors, PET reagent kits and cassettes, to complete radiopharmaceutical drug production in GMP environment.
Based in Radeberg, Germany, and founded in 1997, our team of about 400 employees is specialised in custom synthesis and manufacturing of precursors and peptides according to GMP for active pharmaceutical ingredients. Thanks to our expertise combined with bleeding edge equipment, we reach highest research, production, and quality standards.
ABX is the only service provider of radiopharmaceutical production with a complete and independent supply chain – from precursor or peptide to excipients and sterile disposables.
