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TetraBoc-L-DOPA methyl ester

Copper-mediated 18F-radiofluorination has been extended to the use of arylstannanes as precursors [1]. This method can be used for the 18F-radiosynthesis of [18F]F-L-DOPA under mild conditions and represents a valuable alternative to the technically sophisticated and low-yielding electrophilic approach. Automated 18F-radiofluorination of the TetraBoc protected trimethyltin precusor for clinical use was performed with a radiochemical purity of >99% and a molar activity of up to 60 GBq/µmol [2].

[1] Makaravage K. J. et al. Copper-Mediated Radiofluorination of Arylstannanes with [18F]KF. Org. Lett. 2016, 18, 5440-5443; Zarad F. A Practical Method for the Preparation of 18F-Labeled Aromatic Amino Acids from Nucleophilic [18F]Fluoride and Stannyl Precursors for Electrophilic Radiohalogenation. Molecules 2017, 22, 2231.
[2] Kniess T. et al. Cu-mediated 18F-radioflourination of various stannylated FDOPA precursors - what is feasible? Poster iSRS 2023, Honolulu, Hawaii.

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Why choose ABX? 

ABX advanced biochemical compounds is a global frontrunner in radiopharmaceuticals, with a focus on positron emission tomography (PET) tracers. We develop and produce all compounds and components for any kind of radiotracer – from PET and SPECT precursors, PET reagent kits and cassettes, to complete radiopharmaceutical drug production in GMP environment.

Based in Radeberg, Germany, and founded in 1997, our team of more than 350 employees is specialised in custom synthesis and manufacturing of precursors and peptides according to GMP for active pharmaceutical ingredients. Thanks to our expertise combined with bleeding edge equipment, we reach highest research, production, and quality standards.

ABX is the only service provider of radiopharmaceutical production with a complete and independent supply chain – from precursor or peptide to excipients and sterile disposables. 

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