Several radioligands have been developed as potential radiotracers for molecular imaging of the dopaminergic system using positron emission tomography. [18F]FP-β-CIT is a selective ligand for the dopamine transporter (DAT) but its radiosynthesis is quite difficult and often leads to low radiochemical purity and yield. [18F]FBCTT was developed as an alternative and gives better and reproducible results after radiofluorination. In addition, [18F]FBCTT has a high affinity for DAT and high selectivity over both norepinephrine and serotonin transporters.
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ABX advanced biochemical compounds is a global frontrunner in radiopharmaceuticals, with a focus on positron emission tomography (PET) tracers. We develop and produce all compounds and components for any kind of radiotracer – from PET and SPECT precursors, PET reagent kits and cassettes, to complete radiopharmaceutical drug production in GMP environment.
Based in Radeberg, Germany, and founded in 1997, our team of about 400 employees is specialised in custom synthesis and manufacturing of precursors and peptides according to GMP for active pharmaceutical ingredients. Thanks to our expertise combined with bleeding edge equipment, we reach highest research, production, and quality standards.
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