Small molecules & peptides


Precursor for [¹⁸F]-labeling of N-terminal cysteine-bearing peptides and proteines

2-(2-cyanobenzothiazol-6-yloxy) 4-methylbenzenesulfonate; TE-CBT

CA index name: 2-Benzothiazolecarbonitrile, 6-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]-


Research Chemical


Molar mass 374.44

CAS RN [1392498-16-6]

Purity ≥ 95 %

  • Colorless to yellowish solid


CoA: appearance, ¹H and ¹³C NMR spectra


Ren H. et al. A biocompatible condensation reaction for the labeling of terminal cysteine residues on proteins.Angew. Chem. Int. Ed. 2009, 48, 9658–9662.

Jeon J. et al. Efficient method for site-specific ¹⁸F-labeling of bioMolecules using the rapid condensation reaction between 2-cyanobenzothiazole and cysteine. Bioconjugate Chem. 2012 , 23, 1902 – 1908.

Godinat A. et al. A biocompatible in vivo ligation reaction and its application for noninvasive bioluminescent imaging of protease activity in living mice. ACS Chem. Biol. 2013, 8, 987–999.

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