Small molecules & peptides

PSMA-1007 precursor (GMP)

Precursor for [¹⁸F]PSMA-1007 (PSMA: prostate-specific membrane antigen)

deprotected [¹⁸F]PSMA-1007 precursor; Glu-CO-Lys(2Nal-Amb-Glu-Glu-PyTMA); EuK(2Nal-Amb-Glu-Glu-PyTMA); 5-((S)-4-carboxy-1-((S)-4-carboxy-1-(4-((S)-1-((S)-5-carboxy-5-(3-((S)-1,3-dicarboxypropyl)ureido)pentylamino)-3-(naphthalen-2-yl)-1-oxopropan-2-ylcarbamoyl)benzylamino)-1-oxobutan-2-ylamino)-1-oxobutan-2-ylcarbamoyl)-pyridin-2-yl-trimethylammonium acetate

5-((S)-4-carboxy-1-((S)-4-carboxy-1-(4-((S)-1-((S)-5-carboxy-5-(3-((S)-1,3-dicarboxypropyl)ureido)pentylamino)-3-(naphthalen-2-yl)-1-oxopropan-2-ylcarbamoyl)benzylamino)-1-oxobutan-2-ylamino)-1-oxobutan-2-ylcarbamoyl)-N,N,N-trimethylpyridin-2-aminium acetate


GMP Product


Molar mass 1071.12 (net peptide)

CAS RN [not yet assigned]

  • Colorless to off-white solid


CoA: appearance, ¹H NMR spectrum (identity), MS (identity) , HPLC (Purity)

Product sheets (PDF)


Cardinale J. et al. Procedures for the GMP-Compliant Production and Quality Control of [¹⁸F]PSMA-1007—A Next Generation Radiofluorinated Tracer for the Detection of Prostate Cancer. Preprints 2017, 2017080057 (doi: 10.20944/preprints201708.0057.v1).

Giesel F.L. et al. F-18 labelled PSMA-1007: biodistribution, radiation dosimetry and histopathological validation of tumor lesions in prostate cancer patients. Eur. J. Nucl. Med. Mol. Imaging 2017, 44(4), 678–688. doi: 10.1007/s00259-016–3573–4.

Cardinale J. et al. Preclinical Evaluation of [¹⁸F]PSMA-1007: A New PSMA-Ligand for Prostate Cancer Imaging. J. Nucl. Med. 2016. doi: 10.2967/jnumed.116.181768

Giesel F.L. et al. ¹⁸F-Labelled PSMA-1007 shows similarity in structure, biodistribution and tumour uptake to the theragnostic compound PSMA-617. Eur. J. Nucl. Med. Biol. 2016, 43, 1929–30.

Kesch C. et al. Intra-individual comparison of ¹⁸F-PSMA-1007-PET/CT, multi-parametric MRI and radical prostatectomy specimen in patients with primary prostate cancer - a retrospective, proof of concept study. J Nucl Med. 2017 doi: 10.2967/jnumed.116.18933

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