Small molecules & peptides

6-O-Desmethyl Donepezil

Precursor for [¹¹C]Donepezil

2-[(1-benzylpiperidin-4-yl)methyl]-6-hydroxy-5-methoxyindan-1-one; 2-((1-benzylpiperidin-4-yl)methyl)-6-hydroxy-5-methoxy-2,3-dihydro-1H-inden-1-one; 1-benzyl-[(6-hydroxy-5-methoxy-1-indanon)-2-yl]methylpiperidine; [¹¹C]Donepezil precursor



Research Chemical


Molar mass 365.47

CAS RN [120013-56-1]

Purity ≥ 95 %

  • Colorless solid


CoA: appearance, ¹H NMR spectrum


De Vos F. et al. Pharmacological evaluation of [¹¹C]donepezil as a tracer for visualization of acetylcholinesterase by PET. Nucl. Med. Biol. 2000, 27, 745–747.

Okamura N. et al. In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease. Br. J. Clin. Pharmacol. 2008, 65, 472–479.

Gjerløff T. et al. In vivo imaging of human acetylcholinesterase density in peripheral organs using ¹¹C-donepezil: dosimetry, biodistribution, and kinetic analyses. J. Nucl. Med. 2014, 55, 1818–1824.

Gjerløff T. et al. Imaging acetylcholinesterase density in peripheral organs in Parkinson's disease with ¹¹C-donepezil PET. Brain 2015, 138, 653–663.

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