Small molecules & peptides


Precursor for [¹⁸F]CPFPX (8-cyclopentyl-3-(3-[¹⁸F]fluoropropyl)-1-propylxanthine)

2,2-Dimethyl-propionic acid 8-cyclopentyl-2,6-dioxo-1-propyl-3-[3-(toluene-4-sulfonyloxy)-propyl]-1,2,3,6-tetrahydro-purin-7-ylmethyl ester; 8-Cyclopentyl-3-(3-tosyloxypropyl)-7-pivaloyloxymethyl-1-propylxanthine

CA index name: Propanoic acid, 2,2-dimethyl-, [8-cyclopentyl-1,2,3,6-tetrahydro-3-[3-[[(4-methylphenyl)sulfonyl]oxy]propyl]-2,6-dioxo-1-propyl-7H-purin-7-yl]methyl ester


Research Chemical


Molar mass 588.72

CAS RN [478173-67-0]

Purity ≥ 95 %

  • Colorless solid


CoA: appearance, ¹H NMR spectrum


Holschbach M. H. et al. Synthesis and Evaluation of No-Carrier-Added 8-Cyclopentyl-3-(3-[¹⁸F]fluoropropyl)-1-propylxanthine ([¹⁸F]CPFPX): A Potent and Selective A1-Adenosine Receptor Antagonist for in Vivo Imaging. J. Med. Chem. 2002, 45, 5150–5156.

Bauer A. et al. Evaluation of ¹⁸F-CPFPX, a Novel Adenosine A1 Receptor Ligand: In Vitro Autoradiography and High-Resolution Small Animal PET. J. Nucl. Med. 2003, 44, 1682–1689.

Matusch A. et al. Metabolism of the A1 adenosine receptor PET ligand [¹⁸F]CPFPX by CYP1A2: implications for bolus/infusion PET studies. Nucl. Med. Biol. 2006, 33, 891–898.

Elmenhorst D. et al. Caffeine Occupancy of Human Cerebral A1 Adenosine Receptors: In Vivo Quantification with ¹⁸F-CPFPX and PET. J. Nucl. Med. 2012, 53, 1723–1729.

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Product No.: 3750Filling amount: 10 mg
Product No.: 3750

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