Small molecules & peptides
ASEM standard
Reference standard for [¹⁸F]ASEM
3-(1,4-Diazabicyclo[3.2.2]nonane-4-yl)-6-fluorodibenzo[b,d]thiophene 5,5-dioxide
CA index name: 1,4-Diazabicyclo[3.2.2]nonane, 4-(6-fluoro-5,5-dioxido-3-dibenzothienyl)-
Quality
Research Chemical
Characteristics
Molar mass 358.43
CAS RN [1456878-22-0]
Purity ≥ 95 %
- yellowish solid
- soluble in dimethyl sulfoxide
Certificates
CoA: appearance, ¹H NMR spectrum
Literature
Gao Y. et al. Derivatives of dibenzothiophene for positron emission tomography imaging of α7-nicotinic acetylcholine receptors. J. Med. Chem. 2013, 56, 7574–7589.
Horti A.G. et al. ¹⁸F-ASEM, a Radiolabeled Antagonist for Imaging the α7-Nicotinic Acetylcholine Receptor with PET. J. Nucl. Med. 2014, 55, 672–677.
Wong D.F. et al. Human Brain Imaging of α7 nAChR with [¹⁸F]ASEM: a New PET Radiotracer for Neuropsychiatry and Determination of Drug Occupancy. Mol. Imaging Biol. 2014, 16, 730–738.
Horti A.G. Development of [¹⁸F]ASEM, a specific radiotracer for quantification of the α7-nAChR with positron-emission tomography. Biochem. Pharmacol. 2015, 97, 566–575.
Ravert H.T. et al. Microwave-assisted radiosynthesis of [¹⁸F]ASEM, a radiolabeled α7-nicotinic acetylcholine receptor antagonist. J. Labelled Compd. Radiopharm. 2015, 58, 180–182.
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| Product | Product No. | Filling amount | Quantity | ||
|---|---|---|---|---|---|
| /products/small-molecules-and-peptides/chemical/397c18da-158c-4fd9-a074-2bdb8b79529f | Reference Standard | Product No.: 3372 |
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