Small molecules & peptides

ASEM standard

Reference standard for [¹⁸F]ASEM

3-(1,4-Diazabicyclo[3.2.2]nonane-4-yl)-6-fluorodibenzo[b,d]thiophene 5,5-dioxide

CA index name: 1,4-Diazabicyclo[3.2.2]nonane, 4-(6-fluoro-5,5-dioxido-3-dibenzothienyl)-


Research Chemical


Molar mass 358.43

CAS RN [1456878-22-0]

Purity ≥ 95 %

  • yellowish solid
  • soluble in dimethyl sulfoxide


CoA: appearance, ¹H NMR spectrum


Gao Y. et al. Derivatives of dibenzothiophene for positron emission tomography imaging of α7-nicotinic acetylcholine receptors. J. Med. Chem. 2013, 56, 7574–7589.

Horti A.G. et al. ¹⁸F-ASEM, a Radiolabeled Antagonist for Imaging the α7-Nicotinic Acetylcholine Receptor with PET. J. Nucl. Med. 2014, 55, 672–677.

Wong D.F. et al. Human Brain Imaging of α7 nAChR with [¹⁸F]ASEM: a New PET Radiotracer for Neuropsychiatry and Determination of Drug Occupancy. Mol. Imaging Biol. 2014, 16, 730–738.

Horti A.G. Development of [¹⁸F]ASEM, a specific radiotracer for quantification of the α7-nAChR with positron-emission tomography. Biochem. Pharmacol. 2015, 97, 566–575.

Ravert H.T. et al. Microwave-assisted radiosynthesis of [¹⁸F]ASEM, a radiolabeled α7-nicotinic acetylcholine receptor antagonist. J. Labelled Compd. Radiopharm. 2015, 58, 180–182.

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