Small molecules & peptides
MK-9470 precursor
Precursor for [¹⁸F]MK-9470
Propanamide, N-[(1S,2S)-2-(3- cyanophenyl)-1-methyl-3-[4-[2-[[(4-methylphenyl)sulfonyl]oxy] ethoxy]phenyl]propyl]-2-methyl-2-[(5-methyl-2-pyridinyl)oxy] -; [¹⁸F]MK-9470 precursor; [¹⁸F]MK-9470 tosylate precursor
2-(4-((2S,3S)-2-(3-cyanophenyl)-3-(2-methyl-2-(5-methylpyridin-2-yloxy)propanamido)butyl)phenoxy)ethyl 4-methylbenzenesulfonate
Quality
Research Chemical
Characteristics
Molar mass 641.78
CAS RN [1646148-10-8]
Purity ≥ 95 %
- Colorless to off-white solid
- soluble in dimethyl sulfoxide, chloroform, methanol, ethyl acetate
Certificates
CoA: appearance, ¹H NMR spectrum (identity), HPLC (purity)
Literature
Thomae D. et al. Automated one-step radiosynthesis of the CB1 receptor imaging agent [¹⁸F]MK-9470. J. Labelled Compd. Radiopharm. 2014, 57, 611–614.
Liu P. et al. Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-[4-(2-[¹⁸F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin- 2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use. J. Med. Chem. 2007, 50, 3427–3430.
Burns H.D. et al. [¹⁸F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor. PNAS 2007, 104, 9800–9805.
Emonds K.M. et al. ¹⁸F-MK-9470 PET imaging of the type 1 cannabinoid receptor in prostate carcinoma: a pilot study. EJNMMI Research 2013, 3, 59.
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| Product | Product No. | Filling amount | Quantity | ||
|---|---|---|---|---|---|
| /products/small-molecules-and-peptides/chemical/47a9e42f-59f4-448c-9959-dcf93265e89a | Precursor | Product No.: 5650 |
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