Small molecules & peptides

DOTA-cyclo(RGDfK) acetate

Precursor for radiometal-labelled DOTA-RGD.


Sequence: cyclo[-Arg-Gly-Asp-D-Phe-Lys(DOTA)-]


Research Chemical


Molar mass 990.1 (net peptide)

CAS RN [909024-55-1] (net peptide)

Purity ≥ 95 %

  • Colorless to off-white freeze-dried solid


CoA: appearance, MS (identity), HPLC (purity)


Haukkala J. et al. ⁶⁸Ga-DOTA-RGD peptide: biodistribution and binding into atherosclerotic plaques in mice. Eur. J. Nucl. Med. Mol. Imaging 2009, 36, 2058–2067.

Decristoforo C. et al. ⁶⁸¹¹¹Ga- and ¹¹¹In-labelled DOTA-RGD peptides for imaging of ανβ3 integrin expression. Eur. J. Nucl. Med. Mol. Imaging 2008, 35, 1507–1515.

Yoshimoto M. et al. In Vivo SPECT Imaging with ¹¹¹In-DOTA-c(RGDfK) to Detect Early Pancreatic Cancer in a Hamster Pancreatic Carcinogenesis Model. J. Nucl. Med. 2012, 53, 765–771.

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