Small molecules & peptides

HYNIC-TOC trifluoroacetate

Precursor for [⁹⁹mTc]HYNIC-TOC

HYNIC-[Tyr3] Octreotide; CA index name: L-Cysteinamide, N-[(6-hydrazinyl-3-pyridinyl)carbonyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl- N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2→7)-disulfide

Sequence: HYNIC-D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr(ol), cyclic disulfide; HYNIC = residue of 6-Hydrazinopyridine-3-carboxylic acid; Supplied as trifluoroacetate salt


Research Chemical


Molar mass 1170.40

CAS RN [257943-19-4] (net peptide)

Purity ≥ 95 %

  • Colorless to off-white freeze-dried solid


CoA: appearance, MS (identity), HPLC (purity)


Decristoforo C. et al. ⁹⁹mTc-EDDA/HYNIC-TOC: a new ⁹⁹mTc-labelled radiopharmaceutical for imaging somatostatin receptor-positive tumours - first clinical results and intra-patient comparison with ¹¹¹In-labelled octreotid. Eur. J. Nucl. Med. 2000, 27, 1318–1325.

Decristoforo C. et al. ⁹⁹mTc-HYNIC-[Tyr3]-octreotide for imaging somatostatin-receptor-positive tumors: preclinical evaluation and comparison with ¹¹¹In-octreotide. J. Nucl. Med. 2000, 41, 1114–1119.

Czepczynski R. et al. Somatostatin receptor scintigraphy using ⁹⁹mTc-EDDA/HYNIC-TOC in patients with medullary thyroid carcinoma. Eur. J. Nucl. Med. Mol. Imaging 2007, 34, 1635–45.

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