Small molecules & peptides

DOTA-NOC acetate (GMP)

Precursor for radiolabelled DOTA-NOC

DOTA-[Nal3]-octreotide; CA index name: L-Cysteinamide, N-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-3-(1-naphthalenyl)- L-alanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2→7)-disulfide

Sequence: DOTA-D-Phe-Cys-1Nal-D-Trp-Lys-Thr-Cys-Thr(ol), cyclic disulfide Cys2,7; DOTA = N-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-; Nal = 3-(1-naphthalenyl )-L-alanyl; Supplied as acetate salt


GMP Product


Molar mass 1455.7

CAS RN [619300-53-7] (net peptide)

Purity ≥ 97 %

  • Colorless to off-white solid
  • Tested for bioburden and bacterial endotoxins.


CoA: appearance, ESI-MS (identity), HPLC (purity), GC (residual solvents, acetate content, water content), heavy metal content (ICP-MS), microbiology test


Wild D. et al. ⁶⁸Ga-DOTANOC: a first compound for PET imaging with high affinity for somatostatin receptor subtypes 2 and 5. Eur. J. Nucl. Med. Mol. Imaging 2005, 32, 724.

Wild D. et al. DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labeling with various radiometals. Eur. J. Nucl. Med. Mol. Imaging 2003, 30, 1338–1347.

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