Small molecules & peptides


Reference standard for [¹¹C]MPC-6827

N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine; (4-Methoxyphenyl)(methyl)(2-methylquinazolin-4-yl)amine; MPC-6827; MX-128495; Verubulin, Azixa

4-Quinazolinamine, N-(4-methoxyphenyl)-N,2-dimethyl-


Research Chemical


Molar mass 279.34

CAS RN [827031-83-4]

Purity ≥ 95 %

  • white to off-white solid
  • soluble in dimethyl sulfoxide, chloroform


CoA: appearance, ¹H-and ¹³C-NMR spectra


Kumar, J. S. D. et al. Radiosynthesis and in vivo evaluation of [¹¹C]MPC-6827, the first brain penetrant microtubule PET ligand J. Med. Chem. 2018, DOI: 10.1021/acs.jmedchem.8b00028

Kumar J. S. D, Mann J. J. Radiolabeled microtubule imaging agents and uses thereof. 2017, US patent No. 62/578,903.

Sirisoma, N. et al. Discovery of N-(4-Methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a Potent Apoptosis Inducer and Efficacious Anticancer Agent with High Blood Brain Barrier Penetration J. Med. Chem. 2009 52 (8), 2341–2351.

Kasibhatla, S. et al. A Small-Molecule Inhibitor of Microtubule Formation That Is Not a Substrate for Multidrug Resistance Pumps. Cancer Research 2007, 67 (12), 5865—5871, DOI: 10.1158/0008–5472.CAN-07-0127.

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