Small molecules & peptides
MPC-6827
Reference standard for [¹¹C]MPC-6827
N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine; (4-Methoxyphenyl)(methyl)(2-methylquinazolin-4-yl)amine; MPC-6827; MX-128495; Verubulin, Azixa
4-Quinazolinamine, N-(4-methoxyphenyl)-N,2-dimethyl-
Quality
Research Chemical
Characteristics
Molar mass 279.34
CAS RN [827031-83-4]
Purity ≥ 95 %
- white to off-white solid
- soluble in dimethyl sulfoxide, chloroform
Certificates
CoA: appearance, ¹H-and ¹³C-NMR spectra
Literature
Kumar, J. S. D. et al. Radiosynthesis and in vivo evaluation of [¹¹C]MPC-6827, the first brain penetrant microtubule PET ligand J. Med. Chem. 2018, DOI: 10.1021/acs.jmedchem.8b00028
Kumar J. S. D, Mann J. J. Radiolabeled microtubule imaging agents and uses thereof. 2017, US patent No. 62/578,903.
Sirisoma, N. et al. Discovery of N-(4-Methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a Potent Apoptosis Inducer and Efficacious Anticancer Agent with High Blood Brain Barrier Penetration J. Med. Chem. 2009 52 (8), 2341–2351.
Kasibhatla, S. et al. A Small-Molecule Inhibitor of Microtubule Formation That Is Not a Substrate for Multidrug Resistance Pumps. Cancer Research 2007, 67 (12), 5865—5871, DOI: 10.1158/0008–5472.CAN-07-0127.
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| Product | Product No. | Filling amount | Quantity | ||
|---|---|---|---|---|---|
| /products/small-molecules-and-peptides/chemical/7a35be60-cd1c-48da-89c8-1823e402485e | Reference Standard | Product No.: 2448 |
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