Small molecules & peptides


Precursor for [¹¹C]Rolipram

(±)-Desmethyl-Rolipram; (R,S)-Desmethyl-Rolipram

CA index name: 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-hydroxyphenyl]-


Research Chemical


Molar mass 261.32

CAS RN [150519-28-1]

Purity ≥ 95 %

  • Yellowish solid


CoA: appearance, ¹H NMR spectrum


Kenk M. et al. In vivo selective binding of (R)-[¹¹C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues. Nucl. Med. Biol. 2007, 34, 71–77.

Parker C.A. et al. Behaviour of [¹¹C]R(–)- and [¹¹C]S(+)-rolipram in vitro and in vivo, and their use as PET radiotracers for the quantificative assay of PDE4. Synapse 2005, 55, 270–279.

Lourenco C.M. et al. Characterization of R-[¹¹C]rolipram for PET imaging of phosphodiesterase-4: in vivo binding, metabolism, and dosimetry studies in rats. Nucl. Med. Biol. 2001, 28, 347–358.

Tsukada H. et al. Facilitation of dopaminergic neural transmission does not affect [¹¹C]SCH23390 binding to the striatal D1 dopamine receptors, but the facilitation enhances phosphodiesterase type-IV actvity through D1 receptors: PET studies in the conscious monkey brain. Synapse 2001, 42, 258–265.

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Product No.: 6030Filling amount: 10 mg
Product No.: 6030

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