Small molecules & peptides

MBCTT

Precursor for [¹⁸F]FBCTT (fluorobutynylcarboxymethyltolyltropane)

Mesylbutynylcarboxymethyltolyltropane; (2S,3S,5R)-methyl 8-(4-(methylsulfonyloxy)but-2-ynyl)-3-p-tolyl-8-azabicyclo[3.2.1]octane-2-carboxylate

CA index name: 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-methylphenyl)-8-[4-[(methylsulfonyl)oxy]-2-butyn-1-yl]-, methyl ester, (1R,2S,3S,5S)-

Quality

Research Chemical

Characteristics

Molar mass 405.51

CAS RN [1192248-76-2]

Purity ≥ 95 %

  • colorless solid
  • soluble in chloroform

Certificates

CoA: appearance, 1H-NMR spectrum (identity and purity)

Literature

Riss P.J. et al. Synthesis and monoamine uptake inhibition of conformationally constrained 2β-carbomethoxy-3β-phenyl tropanes. Org. Biomol. Chem. 2009, 7, 2688–2698.

Goggi J.L. et al. Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson’s disease. Stem Cell Res. Ther. 2020, 11, 347.

Riss P.J. et al. Ex vivo and in vivo Evaluation of [18F]PR04.MZ in Rodents: A Selective Dopamine Transporter Imaging Agent. Chem. Med. Chem. 2009, 4, 1480–1487.

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