Small molecules & peptides

Tb-PSMA I&T acetate

Reference Standard for [161Tb]-PSMA I&T (PSMA: prostate-specific membrane antigen I&T: Imaging and Therapy)

159Tb-(R)-DOTAGA-(I-y)fk(Sub-KuE)

Sequence: (R)-DOTAGA(159Tb)-D-Tyr(3-I)-D-Phe-D-Lys[Sub-Glu-CO-Lys] acetate

Quality

Research Chemical

Characteristics

Molar mass 1654,29

CAS RN [not yet assigned]

Purity ≥ 95 %

  • White to off-white solid
  • water, DMSO

Certificates

CoA: appearance, MS (identity), HPLC (purity)

Literature

James P Buteau, MD et.al.First-in-human results of terbium-161 [161Tb]Tb-PSMA-I&T dual beta–Auger radioligand therapy in patients with metastatic castration-resistant prostate cancer (VIOLET): a single-centre, single-arm, phase 1/2 study. The Lancet Oncology, 2025; 26, 1009-1017

Schottelius M. et al. [¹¹¹In] PSMA-I&T: expanding the spectrum of PSMA-I&T applications towards SPECT and radioguided surgery. EJNMMI Res. 2015, 5, 68.


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