Small molecules & peptides

Altropane hydrochloride

Reference standard for [¹¹C]Altropane and Reference standard for [*I]Altropane

(E)-N-(1-Iodoprop-1-en-3-yl)-3-β-(4-fluorophenyl)-nortropane-2-β-carboxylic acid methyl ester, hydrochloride; (E)-N-(3-Iodoprop-2-enyl)-2β-carbomethoxy-3β-(4-fluorophenyl)-nortropane hydrochloride; IACFT HCl

8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-fluorophenyl)-8-[(2E)-3-iodo-2-propenyl]-, methyl ester, (1R,2S,3S,5S)-, hydrochloride salt


Research Chemical


Molar mass 465.73

CAS RN [180468-34-2] (free base)

Purity ≥ 95 %

  • Colorless solid


CoA: appearance, ¹H and ¹⁹F NMR spectra


Fischman A.J. et al. [¹¹C,¹²⁷I] Altropane: a highly selective ligand for PET imaging of dopamine transporter sites. Synapse 2001, 39, 332–342.

Elmaleh D.J. et al. Preparation and biological evaluation of iodine-125-IACFT: a selective SPECT agent for imaging dopamine transporter sites. J. Nucl. Med. 1996, 37, 1197–1202.

Madras B.K. et al. Altropane, a SPECT or PET imaging probe for dopamine neurons: I. Dopamine transporter binding in primate brain. Synapse 1998, 29, 93–104. II. Distribution to dopamine-rich regions of primate brain. Synapse 1998, 29, 105–115 III. Human dopamine tranporter in postmortem normal and Parkinsons brain. Synapse 1998, 29, 116–127.

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