Small molecules & peptides

4-O-Pivaloyl-L-DOPA Hydrochloride

Precursor for 6-[¹⁸F]Fluoro-L-DOPA

3-hydroxy-4-O-pivaloyl-L-phenylalanine hydrochloride; L-3-(3-hydroxy-4-pivaloyloxyphenyl) alanine hydrochloride; 2-Amino-3-[3,4-bis-(2,2-dimethyl-propionyloxy)-phenyl]-propionic acid hydrochloride; pivaloyl-L-dopa hydrochloride; mPdopa HCl

L-Tyrosine, 3-hydroxy-4-(2,2-dimethylpropanoate)


Research Chemical


Molar mass 317.77

CAS RN [122769-71-5]

Purity ≥ 95 %

  • Colorless to nearly colorless solid


CoA: appearance, ¹H NMR spectrum


Bodor N. et al. Improved Delivery through Biological Membranes. 4. Prodrugs of L-Dopa. J. Med. Chem. 1977, 20, 1435–1445.

Ihara M. et al. New Potential Prodrug to Improve the Duration of L-Dopa: L-3-(3-Hydroxy-4-pivaloyloxyphenyl)alanine. J. Pharm. Sci. 1989, 78, 525–529.

Ishiwata K. et al. Electrophilic Synthesis of 6-[¹⁸F]Fluoro-L-DOPA: Use of 4-O-Pivaloyl-L-DOPA as a Suitable Precursor for Routine Production. Appl. Radiat. Isot. 1993, 44, 755–759.

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