Small molecules & peptides

THK-5351 precursor

Precursor for synthesis of [18F]THK-5351

THK-5352; THK-5152S

(2S)-3-((2-(6-(methylamino)pyridin-3-yl)quinolin-6-yl)oxy)-2-((tetrahydro-2H-pyran-2-yl)oxy)propyl 4-methylbenzenesulfonate


Research Chemical


Molar mass 563.67

CAS RN [1707147-35-0]

Purity ≥ 95 %

  • white to off-white solid
  • soluble in chloroform, acetonitrile, dimethyl sulfoxide


CoA: appearance, 1H NMR spectrum (identity), HPLC (purity)


Betthauser, T.J. et al. Characterization of the radiosynthesis and purification of [18F]THK-5351, a PET ligand for neurofibrillary tau. Appl. Radiat. Isot. 2017, 130, 230–237.

Harada, R. et al.18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease. J. Nucl. Med. 2016, 57, 208−214.

Harada, R. et al. Correlations of 18F-THK5351 PET with Postmortem Burden of Tau and Astrogliosis in Alzheimer Disease. J. Nucl. Med. 2018, 59, 671−674.

Add to inquiry

Product No.Filling amountQuantity
Product No.: 5198
Product was added