Small molecules & peptides

FPEB precursor

Precursor for [¹⁸F]FPEB (3-[¹⁸F]fluoro-5-(2-pyridinylethynyl)benzonitrile)

3-[2-(pyridin-2-yl)ethynyl]-5-nitrobenzonitrile; 3-Nitro-5-(pyridinylethynyl)benzonitrile; 3-Nitro-5-pyridin-2-ylethynyl-benzonitrile; Benzonitrile, 3-nitro-5-[2-(-pyridinyl)ethynyl]-

CA index name: Benzonitrile, 3-nitro-5-[2-(2-pyridinyl)ethynyl]-


Research Chemical


Molar mass 249.22

CAS RN [1031370-96-3]

Purity ≥ 95 %

  • Off-white to yellowish/brownish solid


CoA: appearance, ¹H NMR spectrum


Wang J.-Q. et al. Synthesis and Preliminary Biological Evaluation of 3-[¹⁸F]Fluoro-5-(2-pyridinylethynyl)benzonitrile as a PET Radiotracer for Imaging Metrabotropic Glutamate Receptor Subtype 5. Synapse 2007, 61, 951–961.

Alagille D. et al. Potent mGluR5 antagonists: Pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series. Bioorg. Med. Chem. Let. 2011, 21, 3243–3247.

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