Small molecules & peptides

(+)-Fluoromethyl-McN 5652

Reference standard for S-([¹⁸F]Fluoromethyl)-(+)-McN5652

Pyrrolo[2,1-a]isoquinoline, 6-[4-[(fluoromethyl)thio]-phenyl]-1,2,3,5,6,10b-hexahydro-, (6S,10bR)-, (2S,3S)-2,3-di-(O-4-methylphenyloxy)butanedioate; (+)-Fluoromethyl-McN 5652, (–)-di-O-toluyltartrate salt

CA index name: Butanedioic acid, 2,3-bis[(4-methylbenzoyl)oxy]-, (2S,3S)-, compd. with (6S,10bR)-6-[4-[(fluoromethyl)thio]phenyl]-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline (1:1)


Research Chemical


Molar mass 699.79

CAS RN [432038-22-7]

Purity ≥ 95 %

  • Colorless solid


CoA: appearance, ¹H, ¹³C and ¹⁹F NMR spectra, optical rotation


Zessin J. et al. Synthesis of S-([¹⁸F]fluoromethyl)-(+)-McN5652 as a potential PET radioligand for the serotonin transporter. Nucl. Med. Biol. 2001, 28, 857–863.

Solin O. et al. S-[¹⁸F]fluoromethyl-(+)-McN5652, a PET tracer for the serotonin transporter: evaluation in rats. Synapse 2003, 47, 45–53.

Brust P. et al. Positron emission tomography imaging of the serotonin transporter in the pig brain using [¹¹C](+)-McN5652 and S-([¹⁸F]fluoromethyl)-(+)-McN5652. Synapse 2003, 47, 143–151.

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