Small molecules & peptides

Cyclopropyl-p-nitrophenyl ketone

Precursor for [¹⁸F]-labelled building block for different alkylbenzenes (fluorine-18-labelled haloperidol, spiperone, N-(p-nitrobenzyl)spiperone, N-methyl-spiroperidol, BMY14802, 3-N-methyl-benperidol, benperidol)

CA index name: Methanone, cyclopropyl-(4-nitrophenyl)-


Research Chemical


Molar mass 191.18

CAS RN [93639-12-4]

Purity ≥ 99 %

  • Pale yellow needles


CoA: appearance, ¹H NMR spectrum, HPLC


Hashizume K. et al. Rapid and efficient synthesis of high-purity fluorine-18 labeled haloperidol and spiperone via the nitro precursor in combination with a new HPLC separation method. Bull. Chem. Soc. Jpn. 1997, 70, 681–687.

Mach R. H. et al. Synthesis and in vivo evaluation of [¹⁸F]-N-(p-nitrobenzyl)spiperone ([¹⁸F]PNBS) in rats. Nucl. Med. Biol. 1993, 20, 269–278.

Moerlein S.M. et al. Production of fluorine-18-labeled (3-N-methyl)benperidol for PET investigation of cerebral dopaminergic receptor binding. Int. J. Rad. Appl. Instrum. A 1992, 43, 913–917.

Shiue C.Y. et al. Synthesis of (±)-[¹⁸F]BMY14802, its enantiomers and their anatomical distribution in mice. Nucl. Med. Biol. 1993, 20, 625–630.

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