Small molecules & peptides


Ligand for labelling with 99mTc-Tracer

Phosphonic acid, methylenedi-; Medronic acid; Methanebisphosphonic acid; Methanediphosphonic acid; Methylene-1,1-bisphosphonic acid; Methylenebis[phosphonic acid]; Methylenediphosphonic acid; Methylene diphosphonate

CA index name: Phosphonic acid, methylenebis


Research Chemical


Molar mass 176.00

CAS RN [1984-15-2]

Purity ≥ 95 %

  • Colorless solid


CoA: appearance, ¹H and ³¹P NMR spectra


Subramanian G. et al. Technetium-99m-methylene diphosphonate - a superior agent for skeletal imaging: comparison with other technetium complexes. J. Nucl. Med. 1975, 16, 744–755.

Blake G.M. et al. Quantitative Studies of Bone in Postmenopausal Women Using ¹⁸F-Fluoride and 99mTc-Tracer-Methylene Diphosphonate J. Nucl. Med. 2002, 43, 338–345.

Moore A.E.B. et al. Validation of Ultrafiltration as a Method of Measuring Free 99mTc-Tracer-MDP. J. Nucl. Med. 2003, 44, 891–897.

Moore A.E.B. et al. Validation of a Blood-Sampling Method for the Measurement of 99mTc-Tracer-Methylene Diphosphonate Skeletal Plasma Clearance. J. Nucl. Med. 2006, 47, 581–586.

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