Welcome to our next molecule of the month 2024 - SynVesT-2 tin precursor
The synaptic vesicle glycoprotein 2A (SV2A) is expressed ubiquitously in neurons of the central nervous system. Due to the availability of SV2A targeting radiotracers, PET is increasingly used to study a variety of neuropsychiatric diseases. Precursor and reference compounds to synthesize [11C]UCB-J (ABX prod. no. 3420-3423) and [18F]SDM-8/[18F]SynVesT-1 (ABX prod. no. 3425-3428) are available since several years. The SynVesT-2 [1] compounds are the newest addition of SV2A radioligands to the ABX catalogue.
Learn more about this compound and send us your request!
[1] Cai Z. et al. Synthesis and Preclinical Evaluation of an 18F Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [18F]SynVesT 2. ACS Chemical Neuroscience 2020, 11, 592-603; Drake L. R. et al. First-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding. J. Nucl. Med. 2024, 63, 462-469.
Learn more about this compound and send us your request!
[1] Cai Z. et al. Synthesis and Preclinical Evaluation of an 18F Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe: [18F]SynVesT 2. ACS Chemical Neuroscience 2020, 11, 592-603; Drake L. R. et al. First-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding. J. Nucl. Med. 2024, 63, 462-469.