Hypoxia plays a crucial role in tumor biology and influences cancer progression, treatment resistance and patient prognosis [1]. Several fluorinated tracers bearing the nitroimidazole group have been developed for PET hypoxia imaging during recent years[2].
[18F]fluoroimidazole remains the most commonly used PET hypoxia tracer, although the second generation tracer, [18F]FAZA, has more favourable hydrophilicity and can improve signal-to-noise ratio. The [18F]FAZA precursor and reference standard are available from ABX.
[1] KgomotsoM.GMokoala et al. Non-FDG hypoxia tracers. Semin. Nucl. Med. 2024, 54, 827-844.
[2] Yuan Huang et al. Imaging of Tumor Hypoxia With Radionuclide-Labeled Tracers for PET. Front. Oncol. 2021, 11, 731503.
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[18F]fluoroimidazole remains the most commonly used PET hypoxia tracer, although the second generation tracer, [18F]FAZA, has more favourable hydrophilicity and can improve signal-to-noise ratio. The [18F]FAZA precursor and reference standard are available from ABX.
[1] KgomotsoM.GMokoala et al. Non-FDG hypoxia tracers. Semin. Nucl. Med. 2024, 54, 827-844.
[2] Yuan Huang et al. Imaging of Tumor Hypoxia With Radionuclide-Labeled Tracers for PET. Front. Oncol. 2021, 11, 731503.
Learn more about this compound and send us your request!