16α-[¹⁸F]Fluoroestradiol is radiolabeled form of estradiol that allows whole-body, noninvasive evaluation of tissues expressing estrogen receptors (ER). It was the first receptor-targeted PET radiotracer for oncology and has been used as a research agent for several decades.[1]
Recently, 16α-[¹⁸F]Fluoroestradiol has been increasingly used in clinics (under approved INDs, compassionate use programs) for the detection of metastatic ER-positive breast cancer.[2]
[1] Katzenellenbogen, J. A. The Quest for Improving the Management of Breast Cancer by Functional Imaging: The Discovery and Development of 16α-[18F]Fluoroestradiol (FES), a PET Radiotracer for the Estrogen Receptor, an Historical Review. Nucl. Med. Biol. 2021, 92, 24–37.
[2] O’Brien S. R. et al. 18F-Fluoroestradiol: Current Applications and Future Directions. RadioGraphics 2023, 43, 3.
ABX offers the research grade (ABX prod. no. 1900) as well as the GMP precursor (ABX prod. no. 1901) and the reference standard (ABX prod. no. 1910).
Recently, 16α-[¹⁸F]Fluoroestradiol has been increasingly used in clinics (under approved INDs, compassionate use programs) for the detection of metastatic ER-positive breast cancer.[2]
[1] Katzenellenbogen, J. A. The Quest for Improving the Management of Breast Cancer by Functional Imaging: The Discovery and Development of 16α-[18F]Fluoroestradiol (FES), a PET Radiotracer for the Estrogen Receptor, an Historical Review. Nucl. Med. Biol. 2021, 92, 24–37.
[2] O’Brien S. R. et al. 18F-Fluoroestradiol: Current Applications and Future Directions. RadioGraphics 2023, 43, 3.
ABX offers the research grade (ABX prod. no. 1900) as well as the GMP precursor (ABX prod. no. 1901) and the reference standard (ABX prod. no. 1910).