The norepinephrine transporter (NET) is a transmembrane protein involved in catecholamine uptake and is expressed in neuroendocrine tumors such as neuroblastoma. PET radiotracers like [¹⁸F]MFBG are commonly used as imaging agents to assess NET expression or monitor changes during research studies.
Our latest addition to the ABX catalog is the MFBG-SPIAd precursor (ABX-Prod. No. 7038) with a spirocyclic iodonium ylide auxiliary. This precursor enables a straightforward, metal-free and two-step radiosynthesis of the [¹⁸F]MFBG radiotracer and thus represents an alternative to our current pinacol boronate MFBG-precursor (ABX-Prod. No. 7033, 7035).
Both versions of the MFBG precursors and the reference standard (7034) are available for research and development purposes in selected countries worldwide.
Please see more information on product 7038.
Literature reference:
[1] Rotstein, B. H. Mechanistic studies and radiofluorination of structurally diverse pharmaceuticals with spirocyclic iodonium(III) ylides. Chem. Sci. 2016, 7, 4407-4417.
Our latest addition to the ABX catalog is the MFBG-SPIAd precursor (ABX-Prod. No. 7038) with a spirocyclic iodonium ylide auxiliary. This precursor enables a straightforward, metal-free and two-step radiosynthesis of the [¹⁸F]MFBG radiotracer and thus represents an alternative to our current pinacol boronate MFBG-precursor (ABX-Prod. No. 7033, 7035).
Both versions of the MFBG precursors and the reference standard (7034) are available for research and development purposes in selected countries worldwide.
Please see more information on product 7038.
Literature reference:
[1] Rotstein, B. H. Mechanistic studies and radiofluorination of structurally diverse pharmaceuticals with spirocyclic iodonium(III) ylides. Chem. Sci. 2016, 7, 4407-4417.