Small molecules & peptides


Precursor for [¹⁸F]FMISO ([¹⁸F]fluoromisonidazole)

1-(2'-Nitro-1'-imidazolyl)-2-O-tetrahydropyranyl-3-O-toluenesulfonyl-propanediol; 3-(2-Nitroimidazol-1-yl)-2-O-tetrahydropyranyl-1-O-toluenesulfonylpropanediol

CA index name: 1H-imidazole-1-propanol, 2-nitro-β-[(tetrahydro-2H-pyran-2-yl)oxy]-, 4-methylbenzenesulfonate (ester)


Research Chemical


Molar mass 425.46

CAS RN [150196-34-2]

Purity ≥ 95 %

  • Yellowish solid


CoA: appearance, ¹H and ¹³C NMR spectra


Oh S.J. et al. Fully automated synthesis of [¹⁸F]fluoromisonidazole using a conventional [¹⁸F]FDG module. Nucl. Med. Biol. 2005, 32, 899–905.

Lim J.L. et al. An efficient radiosynthesis of [¹⁸F]Fluoromisonidazole. Appl. Radiat. Isot. 1993, 44, 1085–1091.

Martin G.V. et al. Noninvasive detection of hypoxic myocardium using [¹⁸F]Fluoromisonidazole and positron emission tomography. J. Nucl. Med. 1992, 33, 2202–2208.

Rasey J.S. et al. Radiolabeled fluoromisoindazole as an imaging agent for tumor hypoxia. Int. J. Radiat. Oncol. Biol. Phys. 1989, 17, 985–991.

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