Small molecules & peptides

FSPG precursor

Precursor for [¹⁸F]FSPG (S)-4-(3-[¹⁸F]fluoropropyl)-L-glutamic acid

di-tert-butyl (4S)-4-{3-[(2-naphthylsulfonyl)oxy]propyl}-N-trityl-L-glutamate; PI-021, [¹⁸F]FSPG precursor

di-tert-butyl (2S,4S)-2-(3-((naphthalen-2-ylsulfonyl)oxy)propyl)-4-(tritylamino)pentanedioate


Research Chemical


Molar mass 749.95

CAS RN [1407533-12-3]

Purity ≥ 95 %

  • White to yellowish solid
  • soluble in ethyl acetate, diethyl ether, dichloromethane, chloroform, dimethyl sulfoxide, propanol


CoA: appearance, ¹H NMR spectrum (identity), HPLC (purity)


Smolarz K. et al. (S)-4-(3-¹⁸F-Fluoropropyl)-L-glutamic acid: an ¹⁸F-labeled tumor-specific probe for PET/CT imaging - dosimetry. J. Nucl. Med. 2013, 54, 861–866.

Mittra E. S. et al. Pilot Preclinical and Clinical Evaluation of (4S)-4-(3-[¹⁸F]Fluoropropyl)-L-Glutamate (¹⁸F-FSPG) for PET/CT Imaging of Intracranial Malignancies. Plos One 2016, 11.

Domercq M. PET imaging with [¹⁸F]FSPG evidences the role of system xc- on brain inflammation following cerebral ischemia in rats. Theranostics 2016, 6, 1753–1767.

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