Small molecules & peptides

FSPG standard

Reference standard for [¹⁸F]FSPG (S)-4-(3-[¹⁸F]fluoropropyl)-L-glutamic acid

(S)-4-(3-Fluoropropyl)-L-glutamic acid; (4S)-4-(3-Fluoropropyl)-L-glutamate



Research Chemical


Molar mass 207.20

CAS RN [1196794-42-9]

Purity ≥ 95 %

  • White to yellowish solid
  • soluble in methanol


CoA: appearance, ¹H NMR spectrum , ESI-MS


Smolarz K. et al. (S)-4-(3-¹⁸F-Fluoropropyl)-L-glutamic acid: an ¹⁸F-labeled tumor-specific probe for PET/CT imaging - dosimetry. J. Nucl. Med. 2013, 54, 861–866.

Mittra E. S. et al. Pilot Preclinical and Clinical Evaluation of (4S)-4-(3-[¹⁸F]Fluoropropyl)-L-Glutamate (¹⁸F-FSPG) for PET/CT Imaging of Intracranial Malignancies. Plos One 2016, 11.

Domercq M. PET imaging with [¹⁸F]FSPG evidences the role of system xc- on brain inflammation following cerebral ischemia in rats. Theranostics 2016, 6, 1753–1767.

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