Small molecules & peptides


Reference standard [¹⁸F]-(+)-F-PHNO

2H-Naphth[1,2-b]-1,4-oxazin-9-ol, 4-(3-fluoropropyl)-3,4,4a,5,6,10b-hexahydro-, (4aR,10bR)-

CA index name: 2H-Naphtho[1,2-b]-1,4-oxazin-9-ol, 4-(3-fluoropropyl)-3,4,4a,5,6,10b-hexahydro-, (4aR,10bR)-


Research Chemical


Molar mass 265.32

CAS RN [905963-70-4]

Purity ≥ 95 %

  • Colorless to off-white solid


CoA: appearance, ¹H and ¹⁹F NMR spectra


Wilson A.A. et al. [¹¹C]-(+)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol as a Potential Radiotracer for in Vivo Imaging of the Dopamine D2 High-Affinity State with Positron Emission Tomography. J. Med. Chem. 2005, 48, 4153–4160.

Boileau I. et al. Decreased binding of the D3 dopamine receptor-preferring ligand [¹¹C]-(+)-PHNO in drug-naïve Parkinson's disease. Brain, 2009, 132, 1366–1375.

Vasdev N. et al. Syntheses and in vitro evaluation of fluorinated naphthoxazines as dopamine D2/D3 receptor agonists: radiosynthesis, ex vivo biodistribution and autoradiography of [¹⁸F]F-PHNO. Nucl. Med. Biol. 2007, 34, 195–20

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