Small molecules & peptides

DFEAN

Precursor for [¹¹C]FDDNP

2-{1-[6-(2-Fluoro-ethylamino)-naphthalen-2-yl]-ethylidene}-malononitrile

Propanedinitrile, [1-[6-[2-fluoroethyl]amino]-2-naphthalenyl]ethylidene]-

Quality

Research Chemical

Characteristics

Molar mass 279.31

CAS RN [1161260-63-4] ([¹⁸F]DFEAN)

Purity ≥ 95 %

  • Reddish solid

Certificates

CoA: appearance, ¹H, ¹³C and ¹⁹F NMR spectra

Literature

Barrio J. et al. Neurofibrillary tangles (NFTs) and β-amyloid plaques (A-β) demonstrated in vivo in Alzheimer's disease (AD) patients. J. Cereb. Blood Flow Metab. 1999, 19, S2.

Adgeppa E.D. et al. Binding Characteristics of Radiofluorinated 6-Dialkylamino-2-Naphthylethylidene Derivatives as Positron Emission Tomography Imaging Probes for β-Amyloid plaques in Alzheimer's Disease. J. Neurosci. 2001, 21, RC189.

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