Small molecules & peptides

MK-9470 reference standard

Reference standard for [¹⁸F]MK-9470

Propanamide, N-[(1S,2S)-2-(3-cyanophenyl)-3-[4-(2-fluoroethoxy)phenyl]-1-methylpropyl]-2-methyl-2-[(5-methyl-2-pyridinyl)oxy]-; N-{(1S,2S)-2-(3-Cyanophenyl)-3-[4-(2-fluoroethoxy)phenyl)]-1-methylpropyl}-2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide; [¹⁸F]MK-9470 standard



Research Chemical


Molar mass 489.58

CAS RN [947371-30-4]

Purity ≥ 95 %

  • Colorless to off-white solid
  • soluble in dimethyl sulfoxide, chloroform, methanol, ethyl acetate


CoA: appearance, ¹H and ¹⁹F-NMR spectra (identity), HPLC (purity)


Thomae D. et al. Automated one-step radiosynthesis of the CB1 receptor imaging agent [¹⁸F]MK-9470. J. Labelled Compd. Radiopharm. 2014, 57, 611–614.

Liu P. et al. Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-[4-(2-[¹⁸F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin- 2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use. J. Med. Chem. 2007, 50, 3427–3430.

Burns H.D. et al. [¹⁸F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor. PNAS 2007, 104, 9800–9805.

Emonds K.M. et al. ¹⁸F-MK-9470 PET imaging of the type 1 cannabinoid receptor in prostate carcinoma: a pilot study. EJNMMI Research 2013, 3, 59.

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