Small molecules & peptides

(S)-(–)-Normethylcarbamoyl-GR 103545

Precursor for [¹¹C]GR103545

(2S)-2-(3,4-Dichlorophenyl)-1-(2-pyrrolidin-1-ylmethyl-piperazine-1-yl)-ethanon; (2S)-1-[(3,4-Dichlorophenyl)acetyl]-2-(1-pyrrolidinymethyl)piperazine

CA index name: Ethanone, 2-(3,4-dichlorophenyl)-1-[(2S)-2-(1-pyrrolidinylmethyl)-1-piperazinyl]-


Research Chemical


Molar mass 356.29

CAS RN [260992-21-0]

Purity ≥ 95 %

  • Yellowish oil
  • soluble in chloroform, ethanol


CoA: appearance, ¹H NMR spectrum (identity), MS (identity) , HPLC (purity), chiral HPLC (enantiomeric purity)


Ravert H.T. et al. [¹¹C]-GR 89696, a potent kappa opiate receptor radioligand, in vivo binding of the R and S enantiomers. Nuc. Med. Biol. 2002, 29, 47–53.

Talbot P.S. et al. ¹¹C-GR 103545, a Radiotracer for Imaging κ-Opioid Receptors In Vivo with PET: Synthesis and Evaluation in Baboons. J. Nucl. Med. 2005, 46, 484–494.

Naylor A. et al. A Potent New class of κ-Receptor Agonist: 4-Substituted 1-(Arylacetyl)-2-[(dialkylamino)methyl]piperazines. J. Med. Chem. 1993, 36, 2075–2083.

Schoultz B.W. et al. A New Method for Radiosynthesis of ¹¹C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [¹¹C]GR 103545. The Open Med. Chem. J. 2008, 2 ,72–74.

Nabulsi N.B. et al. [¹¹C]GR103545: novel one-pot radiosynthesis with high specific activity. Nucl. Med. Biol. 2011, 38, 215–21.

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