Small molecules & peptides

[¹⁸F]PBR06 precursor

Precursor for [¹⁸F]PBR06

Toluene-4-sulfonic acid [(2,5-dimethoxy-benzyl)-(2-phenoxy-phenyl)-carbamoyl]-methyl ester; Acetamide, N-[(2,5-dimethoxyphenyl)methyl]-2-[[(4-methylphenyl)sulfonyl]oxy]-N-(2-phenoxyphenyl)-

2-((2,5-Dimethoxybenzyl)(2-phenoxyphenyl)amino)-2-oxoethyl 4-methylbenzenesulfonate


Research Chemical


Molar mass 547.62

CAS RN [1334484-14-8]

Purity ≥ 95 %

  • colorless to yellowish solid
  • soluble in dimethyl sulfoxide, chloroform, ethyl acetate


CoA: appearance, ¹H NMR spectrum (identity), HPLC (Purity)


Imaizumi M. et al. Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain. Synapse 2007, 61, 595–605.

Briard E. et al. Single-Step High-Yield Radiosynthesis and Evaluation of a Sensitive ¹⁸F-Labeled Ligand for Imaging Brain Peripheral Benzodiazepine Receptors with PET. J. Med. Chem. 2009, 52, 688–699.

Wang M. et al. Synthesis of [¹¹C]PBR06 and [¹⁸F]PBR06 as agents for positron emission tomographic (PET) imaging of the translocator protein (TSPO). Steroids 2011, 76, 1331–1340.

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