Welcome to our next molecule of the month 2024 - MBCTT
Several radioligands have been developed as potential radiotracers for molecular imaging of the dopaminergic system using positron emission tomography. [18F]FP-β-CIT is a selective ligand for the dopamine transporter (DAT) but its radiosynthesis is quite difficult and often leads to low radiochemical purity and yield. [18F]FBCTT was developed as an alternative and gives better and reproducible results after radiofluorination [1, 2]. In addition, [18F]FBCTT has a high affinity for DAT and high selectivity over both norepinephrine and serotonin transporters.
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MBCTT - Precursor for [¹⁸F]FBCTT (fluorobutynylcarboxymethyltolyltropane)
FBCTT - Reference standard for [¹⁸F]FBCTT (fluorobutynylcarboxymethyltolyltropane)
[1] Patrick J. Riss et al. Ex vivo and in vivo Evaluation of [18F]PR04.MZ in Rodents: A Selective Dopamine Transporter Imaging Agent. ChemMedChem 2009, 4, 1480–1487.
[2] Julian L. Goggi et al. Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson’s disease. Stem Cell Res. Ther. 2020, 11, 347.
Learn more about the related products and send us your request!
MBCTT - Precursor for [¹⁸F]FBCTT (fluorobutynylcarboxymethyltolyltropane)
FBCTT - Reference standard for [¹⁸F]FBCTT (fluorobutynylcarboxymethyltolyltropane)
[1] Patrick J. Riss et al. Ex vivo and in vivo Evaluation of [18F]PR04.MZ in Rodents: A Selective Dopamine Transporter Imaging Agent. ChemMedChem 2009, 4, 1480–1487.
[2] Julian L. Goggi et al. Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson’s disease. Stem Cell Res. Ther. 2020, 11, 347.