Small molecules & peptides

(S)-SDM-8 standard

Reference standard for byproduct of [¹⁸F]SDM-8 synthesis

(S)-4-(3,5-difluorophenyl)-1-((3-methylpyridin-4-yl)methyl)pyrrolidin-2-one; 2-​Pyrrolidinone, 4-​(3,​5-​difluorophenyl)​-​1-​[(3-​methyl-​4-​pyridinyl)​methyl]​-​, (4S)​-; (S)-SDM-8 standard



Research Chemical


Molar mass 302.32

CAS RN [2242777-35-9]

Purity ≥ 95 %

  • Colorless to off-white solid
  • soluble in dimethyl sulfoxide, dichloromethane, methanol, ethyl acetate


CoA: appearance, ¹H and ¹⁹F NMR spectra (identity), HPLC (purity), chiral HPLC (enantiomeric purity)


Li S. et al. Synthesis and in Vivo Evaluation of a Novel PET Radiotracer for Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) in Nonhuman Primates. ACS Chem. Neurosci. 2019, 10, 1544–1554.

Li S. et al. ¹⁸F-SDM-8: A novel radiotracer for PET imaging of synaptic density. J. Nucl. Med. 2018, 59, supplement 1, 68.

Li S. et al. First-in-human Evaluation of ¹⁸F-SDM-8, A Novel Radiotracer for PET Imaging of Synaptic Vesicle Glycoprotein 2A. J. Nucl. Med. 2019, 60, supplement 1, 49.

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